Tag: safety

Did We Screw Up?

Sit back and relax for a minute. I have a short tale that might worry you a bit. One that, if true, would prove to be one of the greatest public health blunders in history. It’s about a vaccine. Wait, wait, don’t go… this isn’t an anti-vax tirade or a rant about mandates. It’s a story about what happens when people rush to make a decision without waiting for all the data.

A question – what happens if we created a “leaky vaccine” and pushed it out to billions of people?

Here’s the background. I follow a number of statisticians. Yes, I know I’m a geek. But I like data and charts and graphs. I admit much of the stats are above my head, but I took just enough statistics to semi-sorta understand what I’m reading. Anyway, I first heard about the idea of leaky vaccines from something that Joe Rogan said on his podcast. He, of course, was immediately blasted for pushing tinfoil hat conspiracy stuff. Which, of course, made me want to read more about it. Enter the statisticians who plot and analyze the data and ignore the politicians and media wisdom.

What you want is a sterilizing vaccine. One that creates an immune response powerful enough that it instantly attacks and wipes out the virus in the host before it can replicate and spread. What you don’t want is a “leaky vaccine” that produces an immune response sufficient to protect the host, but isn’t able to prevent a buildup of viral load or transmission. Every day it’s looking more likely that we’ve produced a pretty leaky covid vaccine. This is generally ok for you, the vaccinated individual. Your immune response protects you from getting really sick. But the population as a whole…

Here’s the worrisome part. The data is showing that when a vaccinated person is hit with covid, their viral load and shedding of virus is equal to that of unvaccinated people and lasts for days. And the best part? Because they have an immune response that starts working to protect them, they are generally asymptomatic. Are the lightbulbs starting to go off? In our mad rush to push the vaccine without sufficient testing, we may have just created a bunch of vaccinated asymptomatic superspreaders, happily walking around and infecting the unvaccinated and those unhealthy folks (vaccinated or not) who managed to dodge the bullet during the first covid wave.

Israel, one of the most vaccinated nations on the planet, got hammered with a second wave. Similarly the UK and many highly vaccinated cities in the US. The hospitals are being overrun in many cities, including my own. In many places it’s far worse than the first covid wave. We’re seeing tons of “breakthrough” cases – vaccinated folks who get covid. Unfortunately many of those folks have multiple comorbidities, which is why they got the vaccine in the first place. Their outcomes aren’t great (but still better than without the vaccine). Get vaccinated so you can safely visit your immunocompromised family and friends! We need a vaccine passport so we can safely shop and go to restaurants! The potential irony would be humorous if it wasn’t so tragic.

It’s a catch-22. The vaccine we rushed into the population is clearly good for the individual, but may be bad for society as a whole. Politicians and public health officials panicked and pushed out something without knowing the potential long term impacts. And now that we’re facing skyrocketing case and fatality rates again, the panicked response is boosters! We need boosters in every arm ASAP!

Never mind that the FDA advisory panel voted 16-2 AGAINST authorizing the booster for everyone. The CDC ignored that and did it anyway. The two top virologists at the FDA resigned over the politicization and handling of all this. Yay! Trust the science bitches.

It’s easy to be an armchair quarterback, I get that. But what makes science all sciency, is a willingness to continually examine the data, re-evaluating, questioning, and rethinking your hypothesis if results weren’t what you expected. Unfortunately politics and fear forced us to throw all that out the window. Politics and vanity will keep anyone from saying out loud, “uh guys, we might have screwed up?” Maybe this is a big nothingburger. Maybe in a couple years this will be a minor, annual flu-like annoyance. Or maybe we’ll be on booster #8 and wondering why we keep getting so many mutating variants? My tinfoil hat fits me just fine, thank you.